National Facility for Structural Biology @Human Technopole

Home News National Facility for Structural Biology @Human Technopole
Dear Fellow Scientists,
It is with great pleasure that we finally announce the official opening of the National Facilities at Human Technopole. The access of external Users affiliated to Universities, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), and Public Research Entities will be supported by open calls for access. Access is granted based on the principles of scientific excellence, with the aim of supporting high-quality research. The quality of the submitted requests is evaluated and approved by an independent panel of experts, the Standing Independent Evaluation Committee, that also defines the Access Management Plan. Access will come at no costs for the selected projects.
The National Facitlity for Structural Biology consists of six Infrastructural Units (IU):
• IU1 – Cryo-Electron Microscopy: This Unit aims at identifying, visualizing, and characterizing biological players of interest, both isolated and within their cellular compartments.
• IU2 – Biomass Production: This Unit provides access to different cell lines for protein expression and performs scale-up of bioprocesses for large-scale productions.
• IU3 – Biophysics: This Unit is a technological platform for biophysical characterization of macromolecules and their interactions
• IU4 – Structural Proteomics: This Unit relies on crosslinking mass spectrometry (XL-MS) to provide topological and structural restraints on protein-protein interactions in samples ranging from purified protein complexes to cellular fractions.
• IU5 – Dynamic Single-molecule: This Unit provides tool to visualize biological processes in real-time with single-molecule sensitivity thanks to cutting-edge instruments that combine optical tweezers with fluorescence and label-free detection modules.
• IU6 – Technology Development: This Unit, planned to be operational in 2026-2028, will be where all other units converge when it comes to pushing technological limitations in the field of integrative structural biology.
National Facility for Structural Biology (Service List + Technical Info):
For general enquiries about the call:
For technical enquiries about the services:
Paolo Swuec
Head of National Facility for Structural Biology
Human Technopole
Palazzo Italia Viale Rita Levi-Montalcini, 1
20157 Milan, Italy

T. +39 02-30247442
M. +39 3427758814